Septicflesh were formed in the 90’s. After a demo entitled “Forgotten Path” and a Mini LP entitled "Temple of the Lost Race" they managed to attract the attention of the French label Holly Records, gaining access to the wider underground scene.Their first full length album entitled "Mystic Places of Dawn" was recorded in April 1994 and gained a very positive response. Then came "Esoptron" that was released in June 1995, a dark opus with deep ancient Hellenic musical influences and themes dealing with philosophy and the occult.

Two years later, "Ophidian Wheel" was released. Female operatic vocals were added to the formula, with the recruit of Natalie Rassoulis. The neo-classical experimentations gained ground, adding a more theatrical dimension to the band’s sound.

In March 1998, a special release entitled "Fallen Temple" was released, presenting both rare old material (the songs of “Temple of the Lost Race” re-recorded) and new material. A limited EP entitled "D.N.A Choronzone" was released in September of the same year, including the video clip for the song "The Eldest Cosmonaut" and 4 special edition tracks.

In June 1999, the band arrived in Sweden to work with Fredrik Nordstrom. The result was "Revolution DNA", an album with highly addictive material and a more straight forward metal attitude.

The first era of the band was concluded with the release of “Sumerian Daemons” in 2002. It was a turning point to a more brutal and bombastic sound.

The next chapter of Septicflesh (with the two words merged together from now on) begun in 2008, as the band signed with French label Season of Mist and released the classic now, "Communion". The album was recorded once again at Fredman Studios in Sweden, with Fredrik Nordstrom as producer. Music-wise, it was a bold step forwards, as the band having ensured the collaboration of the Filmharmonic Orchestra of Prague, decided to fully integrate orchestra to its music. Christos Antoniou, having obtained a Master degree in concert music from the London College of Music, was the obvious choice to take care of the classical arrangements.

In 2011 "The Great Mass" followed. This time, the band collaborated with Peter Tägtgren for the production. The songs were heavy and at the same time highly technical and experimental, as the orchestra was used in a more unconventional way, affecting the structure of the songs. The overall result was a Grand dark metal "soundtrack".

In 2014 the band released "Titan" with Logan Mader as producer. The title of the album pretty much sums up its character. Primordial, menacing and majestic. Besides the steady collaboration with the Filmharmonic Orchestra of Prague, the band utilized for the first time the Children Choir of Prague, adding an eerie tone to the songs.

After an extended period that the band toured all around the world, a change in the line-up occurred, as Kerim "Krimh" Lechner joined the band, taking the position of the drummer. Months of hard work and experimentation followed, resulting to the 10 compositions of the new album "Codex Omega”. Lyrically and musically, “Codex Omega” is by far the most infernal release of Septicflesh to date. The album was produced by another highly acclaimed metal producer, Jens Bogren. Besides the orchestral side represented once again by the Filmharmonic Orchestra of Prague, the band utilized traditional instruments as Oud and Duduk and also a 12 string acoustic-electric guitar, encasing the mystical atmosphere of the compositions. Of course as always “Codex Omega” is dominated by the relentless death guitar riffing and the pale melodies that are the trademark of Septicflesh. Recently Septicflesh have signed with one of the world’s leading record labels, Nuclear Blast Records. On the 2nd of February 2019 the band will perform for the first time in their career with a full Symphony Orchestra and Choir / Children Choir in the Metropolitan Theater of Mexico City.